PURPOSE.The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of Pads daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug.METHODS.CCl4-EHI was induced in rats by a single intraperitoneal injection of CC
Temporal and spatial characterization of keratinocytes supporting orf virus replication
Reflecting their tropism for keratinocytes, most poxviruses that Leather Cleaner infect vertebrates replicate to high titers and cause pathology in the skin.Keratinocytes, the main cells of the epidermis, are found in different stages of a differentiation program that produces the critical barrier against environmental damage.While systemic poxviru
Nano/Microrobots Line Up for Gastrointestinal Tract Diseases: Targeted Delivery, Therapy, and Prevention
Nano/microrobots (NMRs) are tiny devices that can convert energy into motion and operate at nano/microscales.54 Especially in biomedical research, NMRs have received much attention over the past twenty years because of their excellent capabilities and great potential in various applications, including on-demand drug delivery, gene and cell transpor
Local Identity or Economic Benefits? The Municipal Splits in the Czech Republic
This paper studies 38 splits that occurred between 1995 and 2020 in the Czech Republic.Although the initial splits, that took place during the time of democratic transition, were driven by perceived local identity and the historical memory of being a former Yoto Card - Bedtime independent municipality, the splits after 1995 were predominantly drive
Current Approaches in Surface Processing of Biomedical Alloys; Laser Processes
One of the branches of science where great developments are taking place today is biomaterials.Biomaterials are natural or artificial materials that can be used for the replacement of diseased or damaged organs or tissues, and in some cases they can be used for purposes such as correcting body functions or increasing the functionality of organs, re